Maria, absolutely brilliant. Your thought process and knowledge base are more advanced than many specialist MDs. We'll see how Moderna's new T7 RNAP (that eliminates dsRNA) affects vaccine adjuvant response. The entire virus RNA vaccine platform shouldn't even be used for exactly the mechanism reasons you wrote.
Thats very kind of you indeed. I did not include endotoxin as an adjuvant because, well, it is too toxic and besides it is a compendial standard and that is something the regulators will definitely watch.
But yes, this platform will never work as a vaccine. I think the other manufacturers know this and so you don't have other companies racing to make other mRNA vaccines.
Oh they're making all kinds of mRNA vaccines and drugs. The money spigots are opened. Note in the article in science daily they are looking to "boost" the immune response, either with C3d from the complement system OR from more immunogenic lipids. See, they need better adjuvants because either endotoxin or dsRNA are causing myocarditis and other effects. Good luck because this is the central failure of these products, notwithstanding the quantity and duration of protein production.
Or again, self amplifying mRNA which is bonkers. And mRNA in pork. The concern there are the exosomes which last a long long time.
Thank you for what you do. I went to school to be a tech in Illinois, it wasn’t a normal cart class it took a full year. My plan was to take a job as a tech while going to northwestern to become a pharmacist. I had the highest scores in my class, I nailed the certification test, I did my internship at Walgreens, hoping to find my way into a satellite hospital setting for better pay. I had a real love for pharmacology upon starting this adventure, it kept incredibly busy, but the constant revolving door of medications started to raise questions. Also the the way one drug could have 100 different names, and be sold at 100 different prices really got my wheels turning. The list of red flags the pharmacists know as compared to what Dr’s prescribed was also a huge question mark for me. Pharmacy is very precise so I thought Drs were actually prescribing drugs, until I realized they were just selling drugs, and over looking serious red flag complications in the process. I spent 40,000.00 and walked away from my dream, because I could not consciously lie to people. We learned enough about these drugs for me to realize that most of them were only masking the issue, and most of them are much more dangerous then the actual issue. The pharmaceutical industry just like most other industries has a money agenda not a people agenda, unless using people to make money is the agenda!!! It doesn’t take long to figure out that none of these drugs are really safe, it’s a huge chemical guessing game, it’s selfish and immoral all the way around, but we sure do love and trust our family physicians don’t we? I don’t believe that Drs know even half of what pharmacists know about these drugs, and the routes they take through the body, and the way they leave the body or what they leave behind or changed for that matter. Sorry for ranting but have a huge respect for what you are doing here! And just so I don’t sound to pessimistic, I have since found my love in natural medicine although I’m to old to chase a degree!!
Being a pharmacist in retail is a soul sucking experience. All the knowledge, skill and ability, and you're treated like a you work at McDonalds. Drugs are seen as a commodity, and not powerful substances that can heal or cause damage. I think you chose the right path.
I sometimes get a little peeved with docs stating "pharmacists are practising medicine" line because my first response is, thank goodness, because many of you aren't.
I’m not on your level but I completely agree, we talked about sales for a good 4 months, which is ultimately what lead to my disgust for pharmacy. Until that point i always questioned why different drs always had a different go to drug to treat the same symptoms. If there was something really working, why wouldn’t they all be using it. Now Drs don’t even look you over, you walk in they ask a couple questions, they prescribe you a chemical by guessing ,and on to the next.
'Adjuvant lipidoid-substituted lipid nanoparticles augment the immunogenicity of SARS-CoV-2 mRNA vaccines'
Just want to point out that in this paper you cited, one of the corresponding authors is Drew Weissman, who just received the Nobel prize for his work on mRNA vaccines.
Maria, absolutely brilliant. Your thought process and knowledge base are more advanced than many specialist MDs. We'll see how Moderna's new T7 RNAP (that eliminates dsRNA) affects vaccine adjuvant response. The entire virus RNA vaccine platform shouldn't even be used for exactly the mechanism reasons you wrote.
Thats very kind of you indeed. I did not include endotoxin as an adjuvant because, well, it is too toxic and besides it is a compendial standard and that is something the regulators will definitely watch.
But yes, this platform will never work as a vaccine. I think the other manufacturers know this and so you don't have other companies racing to make other mRNA vaccines.
I hope we don't have other companies racing to make other mRNA vaccines, but these articles make me concerned:
https://www.sciencedaily.com/releases/2023/09/230907130332.htm
https://www.nature.com/articles/d41573-022-00035-z
https://arstechnica.com/health/2023/05/experimental-universal-flu-vaccine-with-an-mrna-based-design-enters-trial/
Not the least of which is Sequivity - in (some) pork for FIVE YEARS. https://www.merck-animal-health-usa.com/offload-downloads/merck-sequivity-white-paper
Oh they're making all kinds of mRNA vaccines and drugs. The money spigots are opened. Note in the article in science daily they are looking to "boost" the immune response, either with C3d from the complement system OR from more immunogenic lipids. See, they need better adjuvants because either endotoxin or dsRNA are causing myocarditis and other effects. Good luck because this is the central failure of these products, notwithstanding the quantity and duration of protein production.
Or again, self amplifying mRNA which is bonkers. And mRNA in pork. The concern there are the exosomes which last a long long time.
Yes. Those exosomes are worrisome.
Thank you for what you do. I went to school to be a tech in Illinois, it wasn’t a normal cart class it took a full year. My plan was to take a job as a tech while going to northwestern to become a pharmacist. I had the highest scores in my class, I nailed the certification test, I did my internship at Walgreens, hoping to find my way into a satellite hospital setting for better pay. I had a real love for pharmacology upon starting this adventure, it kept incredibly busy, but the constant revolving door of medications started to raise questions. Also the the way one drug could have 100 different names, and be sold at 100 different prices really got my wheels turning. The list of red flags the pharmacists know as compared to what Dr’s prescribed was also a huge question mark for me. Pharmacy is very precise so I thought Drs were actually prescribing drugs, until I realized they were just selling drugs, and over looking serious red flag complications in the process. I spent 40,000.00 and walked away from my dream, because I could not consciously lie to people. We learned enough about these drugs for me to realize that most of them were only masking the issue, and most of them are much more dangerous then the actual issue. The pharmaceutical industry just like most other industries has a money agenda not a people agenda, unless using people to make money is the agenda!!! It doesn’t take long to figure out that none of these drugs are really safe, it’s a huge chemical guessing game, it’s selfish and immoral all the way around, but we sure do love and trust our family physicians don’t we? I don’t believe that Drs know even half of what pharmacists know about these drugs, and the routes they take through the body, and the way they leave the body or what they leave behind or changed for that matter. Sorry for ranting but have a huge respect for what you are doing here! And just so I don’t sound to pessimistic, I have since found my love in natural medicine although I’m to old to chase a degree!!
Being a pharmacist in retail is a soul sucking experience. All the knowledge, skill and ability, and you're treated like a you work at McDonalds. Drugs are seen as a commodity, and not powerful substances that can heal or cause damage. I think you chose the right path.
I sometimes get a little peeved with docs stating "pharmacists are practising medicine" line because my first response is, thank goodness, because many of you aren't.
I’m not on your level but I completely agree, we talked about sales for a good 4 months, which is ultimately what lead to my disgust for pharmacy. Until that point i always questioned why different drs always had a different go to drug to treat the same symptoms. If there was something really working, why wouldn’t they all be using it. Now Drs don’t even look you over, you walk in they ask a couple questions, they prescribe you a chemical by guessing ,and on to the next.
'Adjuvant lipidoid-substituted lipid nanoparticles augment the immunogenicity of SARS-CoV-2 mRNA vaccines'
Just want to point out that in this paper you cited, one of the corresponding authors is Drew Weissman, who just received the Nobel prize for his work on mRNA vaccines.