Great article even if I don't understand all the chemistry, I do understand the dynamics and the gist of the post. Where I would add or change is to raise t he question about intentional obfuscation of information which has been part of the official narrative. I don't deny the ignoring of pharmacists understanding the biochemistry of the drugs and body systems which I understand is very frustrating. WE do live in a hierarchical society where authority if assigned on a classist basis, a much bigger topic. However, we are also placed under the thumb of huge profiteering institutions; ie, the medical industry, and we know that money and power is what driives them, certainly not real science which would interfere with these goals. As usual, under capitalism it is always about power and profit and any who question or in a position to question will not be allowed.
"If we want high-quality science, we must stop forcing the biology to fit the model and start building models that fit the biology. And get the right people at the table."
Wow. The AI response is insane. Truly revealing. As for LNPs. Thank you for pointing out the tons of things they are doing and influencing! In my book, I discussed a small aspect of LNPs as biologically active entities. That was ignored, too. I never thought LNPs would affect pretty much everything - as you point out. But it makes sense. They can go everywhere and do not just sit around doing nothing other than deliver "the cargo"!
I did read that a biotech company named Alnylam sued pfizer and Moderna for stealing their LNP technology. I read they settled. But, the reason Alnylam didn’t bring it to market was over safety concerns. It wasn’t ready for prime time.
Can you give me a way to read your paper before it gets retracted? As we know, journals are funded by pharma, so chances are the games will begin before retraction. This is all so scary.
The last 5 years exposed the entire science of virology as a pseudo science. I no longer fear anything viral because I know it is all complete BS. I'm a pharmacist as well and very disappointed that most of the profession still sides with the fallacies of virology. All it takes to free your mind is a little research and some critical thinking. Thank you for your analysis, and yes these products have only one intention and that is to cause harm.
I am still wondering if they really wanted to do that harm or just thought “We are so convinced that we can overcome 60 years of biological reality and break through the membrane structure by force that we can test it untested on a mass population level.”?
Drives me the most nuts: I know there are evil people on the top. But the whole field of cell biology, systems biology, pharmacology and signaling transduction?
From data Ingestion: Data (mostly unstructured) is gathered from public online datasets (like Wikipedia and Common Crawl), customer data, industry-specific archives, file shares, object stores, and more.
Wikipedia? Common Crawl?
At the root the computer programmers (human) input information.
So, whatever the current meme is, the current narrative made popular by mass media will get the most input. It is among this database that AI gathers its answers and information.
No...seriously...Maria, you are a friend and colleague and you are making a difference. The world needs to wake up and listen carefully to what you have to say, and take it seriously.
Absolutely: She teached me so much. Without her I wouldn't have sticked the focus on the mechanisms we discussed. And without Maria, no Stephanie Seneff would have listened. We submitted today.
I am so nervous: no PHD, no ORCID and we submitted into a Nature/Springer-hijacked journal.
It’s very frustrating and anger making that ethical scientists are being censored. This is about our life and limb which is of no concern to the psychopaths whose only goal is money. I have been exposed to the massive power pharmaceutical conglomerates have. It’s crushing. I’m injured from one pfizer shot and want to vomit over all the propaganda I believed, anti vaxxer, follow the science, safe and effective, the raging pandemic is going to kill you if you don’t take the shot because herd immunity is impossible without it. Now, on top of an injury I’m also trying to cope with the overwhelming corruption which is censoring shot injuries.
So the narrative that gets published is ranked highly by AI, and those whose submissions are rejected turn to Substack to get their data/opinions out, and it is not ranked highly, creating a fixed narrative loop.
Another problem is that too many pharmacists downgrade their own expertise or don't use their knowledge because they don't want the responsibility. This is why all but a very few of my (former) colleagues took those jabs, and could never accept the responsibility of advising others not to take them. Only a minority of pharmacists had the nerve to dispense alternative therapies or to refer and to recommend the dosages.
Most pharmacists have been their own worst enemies, and will be the first health care professionals to replaced by the very faulty AI. (Think of how many have been willing to work for CVS or Walgreens.)
So true that the LNP delivery system has so many and variable possibilities to interact with cellular structures that we don't have a model to express it.
The mRNA is far beyond being thought of as a pro-drug since there are reverse transcriptase mechanisms by which it can be integrated into the genome. It also can produce many unspecified trash proteins since mRNA causes extra translation errors.
And the contaminant DNA products from the plasmids (also carried in by the lipid nanoparticles) could create innumerable new and heritable effects after being integrated into the genome, either on their own, or most likely by interrupting previously working genetic sequences.
Concerning AI: the LLMs are inherently faulty as they access only a collection of increasingly trashy and/or dishonest collections of words, and rearranges them to interact with those posing questions to them. They generally have shown themselves to be affirmation machines, and will eventually agree with whatever you assert strongly and repeatedly.
I can't trust AI for much other than spellchecking and image production.
Pharmacists are our own worst enemies. It is true. But even those who do not downgrade their expertise or are willing to take responsibility have an uphill battle. Ask me how I know. The LLMs are just a tool. I do find them useful from time to time but you really need to know your material first. And I yell at them a lot when they are wrong and then they perform better. LOL.
You are correct that even the competent pharmacists often don't get the respect, but most also don't stand up for themselves as a rule.
Probably we both could regale each other with crazy stories.
That's what I mean about the LLM being an affirmation machine. It folds whenever challenged, so basically you can make it agree with you. The more you beat it up, the more it sucks up. Useless! You can't trust original output, plus you can bend it to your will. So it can't be relied upon to tell you what you don't already know. It might be slightly useful as a search engine.
I did go through the same thing with Grok. It was not quite as bad as ChatGPT, but pharmacists still seen as less credible. Ditto with Perplexity. It is a systemic bias. I dont know it can be fixed. You can try this yourself. Use domain expertise by you vs physician.
The foundational wrong assumption behind all vaccine models is that introducing a disease causing agent plus toxic adjuvants will be good for human health. It never could be good and mRNA is just another scam. Vaccines are designed to harm, period, whatever they may be called or renamed/rebranded. They are just poison in a vial which sounds like vile for good reason; they are vile.
I agree. I think that’s why the product inserts sent to pharmacists were blank. Quite a few would’ve read them (like I did in Jan 2021 ie the EMA EPAR) and then the questions would’ve started.)
You have demonstrated that the LNP are active mass stimulators of the immune system. And can act as an adjuvant in their own capacity.
We also know that there is a massive downregulation of TP53 following injection.
Do you have any ideas on how this upregulation/downregulation cycle would work?
Especially in the context of LNP being 'stored" in fatty tissues, taken up in exesomes etc only to be recirculated & possibly tranfect into other areas of the body....potentially driving this upregulation/downregulation cycle again? How often could this run? I know this is unanswerable right now. But is anyone looking at the implications of this?
It could cause repeated off-target antigen issues with whatever virus, fungus, bacteria, foodstuffs etc that are in thr body at each repeated cycle?
Sorry, Average Dumb Guy here. So I hope my explanation will be adequate to convey what my minds eye is seeing/thinking
you mean P53? No idea if it is just a SP issue. As for the rest of your question, the re-circulation and sequestration of lipids and mRNA in quiescent cells especially....well I think it can go on for years. I also think the drugs you are taking will affect this, genetics, lifestyle etc. Lots of unanswered questions but we need to get the model of how the "vaccine" works right first. And right now, it is spectacularly wrong
Thanks Maria. But these are all answers that were needed prior to blanket injecting the world with a platform that was knoen fkr decades to be dangerous and have these issues.
But it was assessed using vaccine guidance by immunologists, virologists vaccinologists. No toxicologists, pharmacologists or pharmacists were involved. Anyone asking questions were told to stay in their lane. This is the point of my post. And the AIs enforced the vaccine paradigm.
And this is why I am completely behind you and GB. You are asking the questions that need to be asked. When everyone ignores you, or attacks you. You ARE OVER THE TARGET. KEEP GOING!
Great article even if I don't understand all the chemistry, I do understand the dynamics and the gist of the post. Where I would add or change is to raise t he question about intentional obfuscation of information which has been part of the official narrative. I don't deny the ignoring of pharmacists understanding the biochemistry of the drugs and body systems which I understand is very frustrating. WE do live in a hierarchical society where authority if assigned on a classist basis, a much bigger topic. However, we are also placed under the thumb of huge profiteering institutions; ie, the medical industry, and we know that money and power is what driives them, certainly not real science which would interfere with these goals. As usual, under capitalism it is always about power and profit and any who question or in a position to question will not be allowed.
Thank you for educating me on what pharmacists actually do and capable of doing. I had no idea.
and that is the problem. There are lots of incentives out there to make sure that continues.
The problem isn't the merit based economic system called capitalism.
The problems are lying and stealing.
You will find that the hierarchies are more quickly and rigidly fixed in the top down economic systems called socialism and communism.
Medical industry will angram to 'Is in muddy cartel'. A good description of it.
"If we want high-quality science, we must stop forcing the biology to fit the model and start building models that fit the biology. And get the right people at the table."
- Never a truer word written
Wow. The AI response is insane. Truly revealing. As for LNPs. Thank you for pointing out the tons of things they are doing and influencing! In my book, I discussed a small aspect of LNPs as biologically active entities. That was ignored, too. I never thought LNPs would affect pretty much everything - as you point out. But it makes sense. They can go everywhere and do not just sit around doing nothing other than deliver "the cargo"!
I did read that a biotech company named Alnylam sued pfizer and Moderna for stealing their LNP technology. I read they settled. But, the reason Alnylam didn’t bring it to market was over safety concerns. It wasn’t ready for prime time.
Time to make a difference.
Can you give me a way to read your paper before it gets retracted? As we know, journals are funded by pharma, so chances are the games will begin before retraction. This is all so scary.
They can't retract a pre-print. But they will probably try to refute the peer review process...
The last 5 years exposed the entire science of virology as a pseudo science. I no longer fear anything viral because I know it is all complete BS. I'm a pharmacist as well and very disappointed that most of the profession still sides with the fallacies of virology. All it takes to free your mind is a little research and some critical thinking. Thank you for your analysis, and yes these products have only one intention and that is to cause harm.
I am still wondering if they really wanted to do that harm or just thought “We are so convinced that we can overcome 60 years of biological reality and break through the membrane structure by force that we can test it untested on a mass population level.”?
Drives me the most nuts: I know there are evil people on the top. But the whole field of cell biology, systems biology, pharmacology and signaling transduction?
Where does AI get its information?
From data Ingestion: Data (mostly unstructured) is gathered from public online datasets (like Wikipedia and Common Crawl), customer data, industry-specific archives, file shares, object stores, and more.
Wikipedia? Common Crawl?
At the root the computer programmers (human) input information.
So, whatever the current meme is, the current narrative made popular by mass media will get the most input. It is among this database that AI gathers its answers and information.
Thank you, Maria.
Dr Gutschi you are amazing!!!
No...seriously...Maria, you are a friend and colleague and you are making a difference. The world needs to wake up and listen carefully to what you have to say, and take it seriously.
Thanks David! Much appreciated! But it’s the AI ranking I’m most concerned about.
Absolutely: She teached me so much. Without her I wouldn't have sticked the focus on the mechanisms we discussed. And without Maria, no Stephanie Seneff would have listened. We submitted today.
I am so nervous: no PHD, no ORCID and we submitted into a Nature/Springer-hijacked journal.
It’s very frustrating and anger making that ethical scientists are being censored. This is about our life and limb which is of no concern to the psychopaths whose only goal is money. I have been exposed to the massive power pharmaceutical conglomerates have. It’s crushing. I’m injured from one pfizer shot and want to vomit over all the propaganda I believed, anti vaxxer, follow the science, safe and effective, the raging pandemic is going to kill you if you don’t take the shot because herd immunity is impossible without it. Now, on top of an injury I’m also trying to cope with the overwhelming corruption which is censoring shot injuries.
So the narrative that gets published is ranked highly by AI, and those whose submissions are rejected turn to Substack to get their data/opinions out, and it is not ranked highly, creating a fixed narrative loop.
Science can never progress this way.
This is what is the most upsetting tome. And the narrative loop is wrong. No wonder we can’t make sense of the AEs or anything else.
Good one.
Another problem is that too many pharmacists downgrade their own expertise or don't use their knowledge because they don't want the responsibility. This is why all but a very few of my (former) colleagues took those jabs, and could never accept the responsibility of advising others not to take them. Only a minority of pharmacists had the nerve to dispense alternative therapies or to refer and to recommend the dosages.
Most pharmacists have been their own worst enemies, and will be the first health care professionals to replaced by the very faulty AI. (Think of how many have been willing to work for CVS or Walgreens.)
So true that the LNP delivery system has so many and variable possibilities to interact with cellular structures that we don't have a model to express it.
The mRNA is far beyond being thought of as a pro-drug since there are reverse transcriptase mechanisms by which it can be integrated into the genome. It also can produce many unspecified trash proteins since mRNA causes extra translation errors.
And the contaminant DNA products from the plasmids (also carried in by the lipid nanoparticles) could create innumerable new and heritable effects after being integrated into the genome, either on their own, or most likely by interrupting previously working genetic sequences.
Concerning AI: the LLMs are inherently faulty as they access only a collection of increasingly trashy and/or dishonest collections of words, and rearranges them to interact with those posing questions to them. They generally have shown themselves to be affirmation machines, and will eventually agree with whatever you assert strongly and repeatedly.
I can't trust AI for much other than spellchecking and image production.
Pharmacists are our own worst enemies. It is true. But even those who do not downgrade their expertise or are willing to take responsibility have an uphill battle. Ask me how I know. The LLMs are just a tool. I do find them useful from time to time but you really need to know your material first. And I yell at them a lot when they are wrong and then they perform better. LOL.
You are correct that even the competent pharmacists often don't get the respect, but most also don't stand up for themselves as a rule.
Probably we both could regale each other with crazy stories.
That's what I mean about the LLM being an affirmation machine. It folds whenever challenged, so basically you can make it agree with you. The more you beat it up, the more it sucks up. Useless! You can't trust original output, plus you can bend it to your will. So it can't be relied upon to tell you what you don't already know. It might be slightly useful as a search engine.
Agree completely.
Hi Maria, perhaps you could arrange a debate between ChatGPT, Google AI and Grok?
https://geoffpain.substack.com/p/elon-musk-invites-his-grok-to-read
and
https://geoffpain.substack.com/p/grok-takes-up-my-challenge
and
https://geoffpain.substack.com/p/grok-apologizes-to-me-over-dmso-deaths
and while there you could ask if AI has stopped adding extra limbs to politicians
https://geoffpain.substack.com/p/peter-dutton-performing-backflip
I did go through the same thing with Grok. It was not quite as bad as ChatGPT, but pharmacists still seen as less credible. Ditto with Perplexity. It is a systemic bias. I dont know it can be fixed. You can try this yourself. Use domain expertise by you vs physician.
The foundational wrong assumption behind all vaccine models is that introducing a disease causing agent plus toxic adjuvants will be good for human health. It never could be good and mRNA is just another scam. Vaccines are designed to harm, period, whatever they may be called or renamed/rebranded. They are just poison in a vial which sounds like vile for good reason; they are vile.
Herein lies the crux of literacy, scientific literacy.
I'm sure it is on purpose...no mistakes were made.
I agree. I think that’s why the product inserts sent to pharmacists were blank. Quite a few would’ve read them (like I did in Jan 2021 ie the EMA EPAR) and then the questions would’ve started.)
Thank you for this very interesting piece. I wonder if the LNP interaction is the reason for the "shedding" problem?
short answer. Yes.
If you would please consider expanding on that, I would be very grateful for the long answer...
the mRNA, lipids, maybe even spike protein are exocytosed as exosomes or multivescicle bodies. This is complex but hopefully the summary will help. https://mariagutschi.substack.com/p/transfection-and-endosomal-escape
Hi Maria & GB
Random question.
You have demonstrated that the LNP are active mass stimulators of the immune system. And can act as an adjuvant in their own capacity.
We also know that there is a massive downregulation of TP53 following injection.
Do you have any ideas on how this upregulation/downregulation cycle would work?
Especially in the context of LNP being 'stored" in fatty tissues, taken up in exesomes etc only to be recirculated & possibly tranfect into other areas of the body....potentially driving this upregulation/downregulation cycle again? How often could this run? I know this is unanswerable right now. But is anyone looking at the implications of this?
It could cause repeated off-target antigen issues with whatever virus, fungus, bacteria, foodstuffs etc that are in thr body at each repeated cycle?
Sorry, Average Dumb Guy here. So I hope my explanation will be adequate to convey what my minds eye is seeing/thinking
Or is the downregulation if TP53 purely a SP driven issue? Which could then indicate severity/amount of successful Tranfection?
you mean P53? No idea if it is just a SP issue. As for the rest of your question, the re-circulation and sequestration of lipids and mRNA in quiescent cells especially....well I think it can go on for years. I also think the drugs you are taking will affect this, genetics, lifestyle etc. Lots of unanswered questions but we need to get the model of how the "vaccine" works right first. And right now, it is spectacularly wrong
Thanks Maria. But these are all answers that were needed prior to blanket injecting the world with a platform that was knoen fkr decades to be dangerous and have these issues.
But it was assessed using vaccine guidance by immunologists, virologists vaccinologists. No toxicologists, pharmacologists or pharmacists were involved. Anyone asking questions were told to stay in their lane. This is the point of my post. And the AIs enforced the vaccine paradigm.
And this is why I am completely behind you and GB. You are asking the questions that need to be asked. When everyone ignores you, or attacks you. You ARE OVER THE TARGET. KEEP GOING!
Thanks. Much appreciated. It’s an uphill battle though
Illuminating info. Thank you.