My Dear Lady, if there was ever a pharmacist less washed-up than yourself, I have never met her. I am an old, retired pharmacist who has only in the last five years had time to read and study and actually learn something about viruses, vaccines and so on. Before that, I was just your typical allopathic Pharma parrot. Your articles leave me open-mouthed and in awe. Thank you and please continue.
Thank you for that kind comment. Yeah, I knew some but not a lot on viruses but had experience at taking lots of data and synthesizing it. That came in handy. Feels like i've done enough reading for a PhD or two, just missing the lab work, lol.
Thank you for your informative post regarding the important interactions between clozapine, antiepileptics, and CYP3A4/CYP2C9 substrates, as supported by case reports and reviews. Enhanced monitoring and regulatory studies are essential to ensuring patient safety. However, I am uncertain whether institutions are wise to adopt these practices.
Thanks!!! The CYP2C9 is super interesting and might have changed how the virus was treated. Glad to hear the manufacturers are looking into drug interactions. Hope they include actions on endosomal escape
Thank you, I have been wondering about this for years now. If you watch TV you know the phrase from commercials "dont take XXX if...." and why would that not also apply to the jabs.
Initially, when told that covid deaths were mostly people with co-morbidities, I wondered if there was more to it then just that they were in a weakened condition. What co-morbid isn't also on a slew of drugs? So you could have said most covid deaths were people taking multiple other drugs, and perhaps a bad drug interaction was involved. It did not occur to me that some of the drugs people were on might have been beneficial with respect to covid.
Thankfully the manufacturers have promised to look into the drug-drug interactions,
"Could they have helped with dampening the effect of the vaccines if given at the same time?"
There are patient groups who would be taking statins, dexamethasone, ritonavir, etc. long-term. I feel like we would've stumbled across a signal by now. (Certainly it is known that immunosuppressed patients don't make much antibodies post-vax.)
Regarding IVM, p-glycoprotein is an efflux pump so technically it does not metabolize IVM?
yes, p-glycoprotein is an efflux pump but like CY450 you have substrates, inducers and inhibitors, so conventionally we classify them together.
There's a lot of confounders, so a signal could be missed unless it is looked at systemically. Montelukast in particular, which I will talk about next.
The only drug reaction that interests me are the reactions resulting from interactions with all the still living people who took the shot, took the booster, and out loud bragged about it
My Dear Lady, if there was ever a pharmacist less washed-up than yourself, I have never met her. I am an old, retired pharmacist who has only in the last five years had time to read and study and actually learn something about viruses, vaccines and so on. Before that, I was just your typical allopathic Pharma parrot. Your articles leave me open-mouthed and in awe. Thank you and please continue.
Thank you for that kind comment. Yeah, I knew some but not a lot on viruses but had experience at taking lots of data and synthesizing it. That came in handy. Feels like i've done enough reading for a PhD or two, just missing the lab work, lol.
I wish Maria's excellent insights would reach a greater audience. So much important material - could it all be compiled as a book?
Thank you for your informative post regarding the important interactions between clozapine, antiepileptics, and CYP3A4/CYP2C9 substrates, as supported by case reports and reviews. Enhanced monitoring and regulatory studies are essential to ensuring patient safety. However, I am uncertain whether institutions are wise to adopt these practices.
Thanks!!! The CYP2C9 is super interesting and might have changed how the virus was treated. Glad to hear the manufacturers are looking into drug interactions. Hope they include actions on endosomal escape
Thank you, I have been wondering about this for years now. If you watch TV you know the phrase from commercials "dont take XXX if...." and why would that not also apply to the jabs.
Initially, when told that covid deaths were mostly people with co-morbidities, I wondered if there was more to it then just that they were in a weakened condition. What co-morbid isn't also on a slew of drugs? So you could have said most covid deaths were people taking multiple other drugs, and perhaps a bad drug interaction was involved. It did not occur to me that some of the drugs people were on might have been beneficial with respect to covid.
Thankfully the manufacturers have promised to look into the drug-drug interactions,
"Could they have helped with dampening the effect of the vaccines if given at the same time?"
There are patient groups who would be taking statins, dexamethasone, ritonavir, etc. long-term. I feel like we would've stumbled across a signal by now. (Certainly it is known that immunosuppressed patients don't make much antibodies post-vax.)
Regarding IVM, p-glycoprotein is an efflux pump so technically it does not metabolize IVM?
yes, p-glycoprotein is an efflux pump but like CY450 you have substrates, inducers and inhibitors, so conventionally we classify them together.
There's a lot of confounders, so a signal could be missed unless it is looked at systemically. Montelukast in particular, which I will talk about next.
Was assessing drug-interactions a requirement included in Health Canada's terms and conditions?
No required under vaccine guidance, so no. And no terms or conditions
The Spike-Protein binds to polysorbate 80 leadig to vlps https://drbine.substack.com/p/achtung-eine-impfung-mit-polysorbat
The only drug reaction that interests me are the reactions resulting from interactions with all the still living people who took the shot, took the booster, and out loud bragged about it